Endocrine Abstracts

Orexins, in addition to regulating food intake and playing a role in the sleep wake cycle, are involved in the activation of HPA axis. Starvation induces metabolic changes in the body, including upregulation of orexin and its receptors in the hypothalamus. We investigated the expression and signalling characteristics of rat orexin receptors at the hypothalamic and adrenal level in food deprived animals and controls. Food deprivation induced both orexin type-1 (OX1R) and type-2...